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Search your favorite messages, view full conversations in thread format and keep your messages longer. Data generated for products targeting CTLA-4 and other checkpoint markers has shown that prevention of these inhibitory signals can restore or enhance tumour killing and a number of checkpoint inhibitor products are now in the clinic or development. Other approaches under evaluation include stimulation of in vivo formation and expansion of Tregs using nanoparticles coated with disease-relevant peptide-major histocompatibility complexes pMHCs. However, 15 years later, it has become clear that our genes alone cannot predict susceptibility to complex disease or fully explain fundamental aspects of human development and aging. In addition, due to the very specific nature of epigenetic biomarkers, these technologies may enable the identification of ctDNA tissue-of-origin as well as the stage of disease.

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